waaQ

Lipopolysaccharide core heptosyltransferase 3

Validation StatusCandidate

Overview

Mechanism: LPS biosynthesis
Validation Method: Gene knockout and MIC testing
Drug Classes: Tilmicosin, Erythromycin, Azithromycin, Tigecycline
Organisms: Escherichia coli ETEC5621, Escherichia coli K-12 MG1655, Escherichia coli
Geographic Location: Denmark
Papers: 2
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A109T	-	-	Escherichia coli	Tigecycline	Reslit	Candidate
L153V	-	-	Escherichia coli	Tigecycline	Reslit	Candidate

Papers2

The intrinsic macrolide resistome of Escherichia coli.

PMID 38940570 · 2024

The study identified several genes involved in intrinsic macrolide resistance in E. coli, including surA, waaG, acrA, acrB, tolC, lptC, bamB, lpp, tolA, tolB, tolR, waaQ, gmhB, galU, waaP, lapC, prc, nlpI, hrpA, and pgm. These genes are associated with outer membrane integrity, efflux pumps, LPS biosynthesis, and peptidoglycan metabolism.

Gene Information

Gene Name: waaQ
Allele: waaQ
Encodes: Lipopolysaccharide core heptosyltransferase 3
Source Database: Reslit
Mechanism: LPS biosynthesis
Confers Resistance To: TilmicosinErythromycinAzithromycin
Organisms Tested In: • Escherichia coli ETEC5621
• Escherichia coli K-12 MG1655
Geographic Location: Denmark
Validation Method: Gene knockout and MIC testing
Sequence Accession: U00096.3

Browse AMR Genes

waaQ

Mutations

Gene Information