waaY

lipopolysaccharide core biosynthetic function

Validation StatusSupported

Overview

Mechanism: upregulation increases negative surface charge of the bacterial outer membrane, enhancing susceptibility to antimicrobial peptides
Validation Method: phenotypic microarray analysis and gene disruption experiments
Organisms: Escherichia coli, Salmonella typhimurium
Papers: 3
Databases: Reslit

Papers3

SoxRS-mediated lipopolysaccharide modification enhances resistance against multiple drugs in Escherichia coli.

PMID 19376854 · 2009

The study identifies waaY and waaZ as genes involved in lipopolysaccharide modification, enhancing resistance against multiple drugs and oxidants in Escherichia coli.

Gene Information

Gene Name: waaY
Allele: waaY
Encodes: lipopolysaccharide core biosynthetic function
Source Database: Reslit
Organisms Tested In: • Escherichia coli
Validation Method: phenotypic microarray analysis and gene disruption experiments

Mechanisms and fitness costs of resistance to antimicrobial peptides LL-37, CNY100HL and wheat germ histones.

PMID 23894360 · 2013

The study identifies mutations in waaY, pmrB, and phoP as responsible for resistance to antimicrobial peptides LL-37, CNY100HL, and wheat germ histones in Salmonella typhimurium. These mutations confer cross-resistance to multiple peptides and are associated with fitness costs.

Gene Information

Gene Name: waaY
Allele: waaY
Encodes: LPS core modification enzyme
Source Database: Reslit
Organisms Tested In: • Salmonella typhimurium
Validation Method: whole genome sequencing and reconstitution
Sequence Accession: SRP023134|NCBI BioProject PRJNA176023

Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.

PMID 29795541 · 2018

Antibiotic-resistant bacteria exhibit widespread collateral sensitivity to antimicrobial peptides, particularly PGLA. Mutations in marR, ompC, and sbmA contribute to this sensitivity by altering membrane properties and efflux mechanisms.

Gene Information

Gene Name: waaY
Allele: waaY
Encodes: kinase responsible for phosphorylation of the inner core of LPS
Source Database: Reslit
Mechanism: upregulation increases negative surface charge of the bacterial outer membrane, enhancing susceptibility to antimicrobial peptides
Organisms Tested In: • Escherichia coli
Validation Method: qRT-PCR analysis confirmed that waaY is nearly 4-fold upregulated in the marR single-mutant strain when compared to the wild-type

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