wcaJ

capsule biosynthesis protein

Validation StatusCandidate

Overview

Mechanism: mutation leading to resistance
Validation Method: whole genome sequencing and MIC testing
Drug Classes: Cephalothin, Cefoxitin, Ceftazidime
Organisms: Klebsiella pneumoniae 43816, Klebsiella pneumoniae
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G317R	-	-	Klebsiella pneumoniae	Ceftazidime	Reslit	Candidate
G317D	-	-	Klebsiella pneumoniae	Ceftazidime	Reslit	Candidate

Papers3

Progressive Sub-MIC Exposure of Klebsiella pneumoniae 43816 to Cephalothin Induces the Evolution of Beta-Lactam Resistance without Acquisition of Beta-Lactamase Genes.

PMID 37237790 · 2023

The study shows that progressive sub-MIC exposure of Klebsiella pneumoniae 43816 to cephalothin leads to the evolution of beta-lactam resistance through mutations in rpoB, tetR/acrR, and wcaJ, without acquiring beta-lactamase genes.

Gene Information

Gene Name: wcaJ
Allele: wcaJ
Encodes: capsule biosynthesis protein
Source Database: Reslit
Mechanism: mutation leading to resistance
Confers Resistance To: CephalothinCefoxitin
Organisms Tested In: • Klebsiella pneumoniae 43816
Validation Method: whole genome sequencing and MIC testing
Sequence Accession: PMC10215138|PRJNA854906

Evolution of phage resistance in hypervirulent Klebsiella pneumoniae SCNJ1 and its impact on bacterial fitness and virulence

PMID 39966630 · 2023

The study identifies mutations in wcaJ, wzc, and bglA as key determinants of phage resistance in hypervirulent Klebsiella pneumoniae SCNJ1, highlighting their roles in capsule deficiency and altered phage adsorption.

Gene Information

Gene Name: wcaJ
Allele: wcaJ
Encodes: glycosyltransferase
Source Database: Reslit
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: genetic mutation analysis and phage adsorption experiments
Sequence Accession: PRJNA1190331

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wcaJ

Mutations

Gene Information

Gene Information