wecA

undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase

Validation StatusSupported

Overview

Mechanism: nonsense variant in wecA
Validation Method: knock-in approach
Drug Classes: Imipenem, Meropenem, Polymyxin b
Organisms: Escherichia coli, Klebsiella pneumoniae, Enterobacter hormaechei, Helicobacter pylori
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R40C	-	-	Escherichia coli, Klebsiella pneumoniae	Imipenem	Reslit	Candidate
-	G118A	-	Escherichia coli, Klebsiella pneumoniae	Imipenem	Reslit	Candidate

Papers3

Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria.

PMID 31744905 · 2019

The study identified several genes and mutations associated with imipenem resistance in Gram-negative bacteria, including rpoD, amiC, nlpD, wecA, slt, and oprD, through mutagenesis and functional validation experiments.

Gene Information

Gene Name: wecA
Allele: wecA
Encodes: undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
Source Database: Reslit
Confers Resistance To: Imipenem
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
Validation Method: knock-in approach
Sequence Accession: PRJNA244551|PRJNA244567|PRJNA316664

The evolution of antibiotic resistance in an incurable and ultimately fatal infection: A retrospective case study.

PMID 37325804 · 2023

The study identifies multiple mutations in genes such as ampD, deoR, wecA, rcsC, ompC, ompD, and phoE that contribute to antibiotic resistance in Enterobacter hormaechei. These mutations include transposon insertions, deletions, and frameshift variants, leading to resistance against β-lactams, carbapenems, and other antibiotics.

Gene Information

Gene Name: wecA
Allele: wecA
Encodes: involved in O-antigen production
Source Database: Reslit
Mechanism: nonsense variant in wecA
Confers Resistance To: Meropenem
Organisms Tested In: • Enterobacter hormaechei
Validation Method: whole-genome sequencing and phenotypic testing
Sequence Accession: CP023569|CP027111

Roles of Lipopolysaccharide Glycosyltransferases in Maintenance of Helicobacter pylori Morphology, Cell Wall Permeability, and Antimicrobial Susceptibilities.

PMID 37511140 · 2023

Deletion of the wecA gene in H. pylori significantly increased susceptibility to polymyxin B and rifampicin, indicating its role in resistance mechanisms.

Gene Information

Gene Name: wecA
Allele: wecA
Encodes: glycosyltransferase
Source Database: Reslit
Confers Resistance To: Polymyxin b
Organisms Tested In: • Helicobacter pylori
Validation Method: MIC testing

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wecA

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