whiB4

transcription factor

Validation StatusCandidate

Overview

Validation Method: MIC testing and gene expression analysis
Drug Classes: Amoxicillin, Ampicillin, Cloxacillin, Carbenicillin, Meropenem, Penicillin
Organisms: Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis.

PMID 28548640 · 2017

The study identifies BlaC as a β-lactamase in Mycobacterium tuberculosis that contributes to β-lactam resistance, and shows that WhiB4 modulates its expression in a redox-dependent manner.

Gene Information

Gene Name: whiB4
Allele: whiB4
Encodes: transcription factor
Source Database: Reslit
Confers Resistance To: AmoxicillinAmpicillinCloxacillinCarbenicillinMeropenemPenicillin
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: MIC testing and gene expression analysis

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whiB4

Gene Information