whiB6

transcriptional regulator

Validation StatusCandidate

Overview

Mechanism: under positive selection
Validation Method: genome-wide association study
Drug Classes: CAP, KAN, Kanamycin
Organisms: Mycobacterium tuberculosis
Geographic Location: Moldova|global, Peru
Papers: 3
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T2A	-	-	Mycobacterium tuberculosis	Kanamycin	Reslit	Candidate

Papers3

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions.

PMID 31086182 · 2019

The study identifies 12 genetic regions and one single nucleotide substitution associated with resistance in Mycobacterium tuberculosis, highlighting the role of non-canonical loci and promoter regions in antibiotic resistance.

Gene Information

Gene Name: whiB6
Allele: whiB6
Encodes: transcriptional regulator
Source Database: Reslit
Confers Resistance To: CAPKAN
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Peru
Validation Method: genome-wide association study

Evaluating selection at intermediate scales within genes provides robust identification of genes under positive selection in M. tuberculosis clinical isolates.

PMID 41033137 · 2025

The study identifies genes under positive selection in M. tuberculosis clinical isolates, including several known drug-resistance genes such as rpoB, gyrA, gidB, pncA, embB, and ubiA. It highlights the importance of analyzing selection at intermediate scales within genes for accurate identification of resistance-associated genes.

Gene Information

Gene Name: whiB6
Allele: whiB6
Encodes: transcription factor
Source Database: Reslit
Mechanism: under positive selection
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Moldova|global
Validation Method: positive selection analysis

Browse AMR Genes

whiB6

Mutations

Gene Information

Gene Information