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ResLit

wzc

capsule synthesis protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to wzc

AMR Rules

Browse AMR rules for wzc

Validation StatusSupported

Overview

Mechanism: inactivation by IS102 element
Validation Method: population sequencing and MIC testing
Drug Classes: Colistin, Tigecycline, Carbapenem
Organisms: Klebsiella pneumoniae, Acinetobacter baumannii
Geographic Location: Europe, The Netherlands|United Kingdom
Papers: 5
Databases: Reslit
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G565S	-	-	-	Carbapenem	Reslit	Candidate
I402S	-	-	-	Carbapenem	Reslit	Candidate
D567Y	-	-	Klebsiella pneumoniae	Carbapenem	Reslit

Papers5

Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics.

PMID 33139278 · 2020

The study identifies multiple genetic mutations and insertions associated with colistin resistance in Klebsiella pneumoniae complex strains, including mutations in phoP, phoQ, crrAB, crrC, wzc, rho, and lptD, as well as insertions of IS5 and IS102 elements.

Gene Information

Gene Name: wzc
Allele: wzc
Encodes: capsule synthesis protein
Source Database: Reslit
Mechanism: inactivation by IS102 element
Confers Resistance To: Colistin
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: The Netherlands|United Kingdom
Validation Method: population sequencing and MIC testing
Sequence Accession: PRJEB29521

Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter baumannii in Critically Ill Patients.

PMID 35044218 · 2022

The study identifies several genes and mutations associated with tigecycline resistance in Acinetobacter baumannii, including baeR, wzc, aroQ, rluC, adeS, and IS Aba1. These genetic elements contribute to the development of tigecycline resistance in clinical isolates from critically ill patients.

Gene Information

Gene Name: wzc
Allele: wzc
Encodes: Tyrosine protein kinase
Source Database: Reslit
Mechanism: Missense mutation
Confers Resistance To: Tigecycline
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Europe
Validation Method: genomic variation analysis
Sequence Accession: JAHWVM000000000|JAHWVL000000000|JAHWVK000000000|JAHWVJ000000000|JAHWVI000000000|JAHWVH000000000|JAHWVG000000000|JAHWVF000000000|JAHWVE000000000|CP079942|JAHWWA000000000|JAHWVZ000000000|JAHWVY000000000|JAHWVX000000000|JAHWVW000000000|JAHWVV000000000|CP079945|JAHWVU000000000|JAHWVT000000000|JAHWVS000000000|JAHWVR000000000|JAHWVQ000000000|JAHWVP000000000|JAHWVO000000000|JAHWVN000000000

Evolution of phage resistance in hypervirulent Klebsiella pneumoniae SCNJ1 and its impact on bacterial fitness and virulence

PMID 39966630 · 2023

The study identifies mutations in wcaJ, wzc, and bglA as key determinants of phage resistance in hypervirulent Klebsiella pneumoniae SCNJ1, highlighting their roles in capsule deficiency and altered phage adsorption.

Gene Information

Gene Name: wzc
Allele: wzc
Encodes: tyrosine-protein kinase
Source Database: Reslit
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: genetic mutation analysis and phage adsorption experiments
Sequence Accession: PRJNA1190331