ybjX

unknown function

Validation StatusCandidate

Overview

Mechanism: cell envelope remodeling
Validation Method: knock-out mutant studies and real-time PCR
Drug Classes: Benzalkonium chloride, Colistin
Organisms: Escherichia coli
Papers: 2
Databases: Reslit

Papers2

Subminimal inhibitory concentrations of the disinfectant benzalkonium chloride select for a tolerant subpopulation of Escherichia coli with inheritable characteristics.

PMID 22605968 · 2012

Exposure to sub-minimal inhibitory concentrations of benzalkonium chloride selects for a tolerant subpopulation of E. coli, involving upregulation of the acrB efflux gene, downregulation of ompF, and a point mutation in rpsA.

Gene Information

Gene Name: ybjX
Allele: ybjX
Encodes: unknown function
Source Database: Reslit
Mechanism: cell envelope remodeling
Confers Resistance To: Benzalkonium chloride
Organisms Tested In: • Escherichia coli
Validation Method: knock-out mutant studies and real-time PCR
Sequence Accession: NCBI:CP003047|NCBI:CP003048|NCBI:CP003049

Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli.

PMID 35680894 · 2022

The study identifies basS and basR as essential for colistin resistance in E. coli, and confirms the role of gyrA and parC mutations in ciprofloxacin resistance through experimental validation.

Gene Information

Gene Name: ybjX
Allele: ybjX
Encodes: hypothetical protein
Source Database: Reslit
Confers Resistance To: Colistin
Organisms Tested In: • Escherichia coli
Validation Method: reversion of mutations in evolved clones
Sequence Accession: PRJNA543834

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ybjX

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