yrfF

essential regulator of bacterial capsule synthesis

Validation StatusCandidate

Overview

Mechanism: disruption of yrfF, which confers mucoidy and increased virulence
Validation Method: experimental proof of mucoid phenotype and resistance to phagocytic killing
Organisms: Escherichia coli
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	C123T	-	Escherichia coli	-	Reslit	Candidate

Papers2

Novel Phagocytosis-Resistant Extended-Spectrum β-Lactamase-Producing Escherichia coli From Keratitis.

PMID 27631542 · 2016

A novel mucoid variant of the extensively drug-resistant ST131 lineage of ESBL-producing E. coli was isolated from a corneal ulcer, with a novel in-frame deletion in yrfF conferring mucoidy and increased phagocytosis resistance.

Gene Information

Gene Name: yrfF
Allele: yrfF
Encodes: essential regulator of bacterial capsule synthesis
Source Database: Reslit
Mechanism: disruption of yrfF, which confers mucoidy and increased virulence
Organisms Tested In: • Escherichia coli
Validation Method: experimental proof of mucoid phenotype and resistance to phagocytic killing
Sequence Accession: PMC5106311

Browse AMR Genes

yrfF

Mutations

Gene Information