ysaC

ATPase subunit of the ABC transporter YsaCB

Validation StatusCandidate

Overview

Mechanism: Mutations in ysaC lead to resistance to bacteriocins and membrane-targeting antibiotics
Validation Method: Genome sequencing and sensitivity assays
Drug Classes: Daptomycin, Daptomycin|Gramicidin
Organisms: Lactococcus lactis
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S208I	-	-	Lactococcus lactis	Daptomycin\|Gramicidin	Reslit	Candidate

Papers1

Lactococcus lactis Resistance to Aureocin A53- and Enterocin L50-Like Bacteriocins and Membrane-Targeting Peptide Antibiotics Relies on the YsaCB-KinG-LlrG Four-Component System.

PMID 34516250 · 2021

The study identifies mutations in the YsaCB-KinG-LlrG system that confer resistance to Aureocin A53- and Enterocin L50-like bacteriocins and membrane-targeting antibiotics in Lactococcus lactis.

Gene Information

Gene Name: ysaC
Allele: ysaC
Encodes: ATPase subunit of the ABC transporter YsaCB
Source Database: Reslit
Mechanism: Mutations in ysaC lead to resistance to bacteriocins and membrane-targeting antibiotics
Confers Resistance To: Daptomycin
Organisms Tested In: • Lactococcus lactis
Validation Method: Genome sequencing and sensitivity assays
Sequence Accession: WP_003244535.1|WP_063644489.1

Browse AMR Genes

ysaC

Mutations

Gene Information