yvlB

putative target of LiaFSR signaling pathway

Validation StatusCandidate

Overview

Mechanism: cell envelope stress response
Validation Method: whole-genome sequencing and allelic frequency measurements
Drug Classes: Daptomycin
Organisms: Enterococcus faecalis
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V289fs	-	frameshift mutation	Enterococcus faecalis	Daptomycin	Card Database	Established

Papers1

Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance.

PMID 23959318 · 2013

The study identified mutations in the liaF, liaR, yvlB, and cls genes that contribute to daptomycin resistance in Enterococcus faecalis through a defined evolutionary pathway involving the LiaFSR signaling pathway and changes in membrane composition.

Gene Information

Gene Name: yvlB
Allele: yvlB
Encodes: putative target of LiaFSR signaling pathway
Source Database: Reslit
Mechanism: cell envelope stress response
Confers Resistance To: Daptomycin
Organisms Tested In: • Enterococcus faecalis
Validation Method: whole-genome sequencing and allelic frequency measurements
Sequence Accession: SRP029594

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yvlB

Mutations

Gene Information