yybT

peptide permease

Validation StatusCandidate

Overview

Validation Method: whole-genome sequencing
Drug Classes: DAPTOMYCIN, Daptomycin
Organisms: Enterococcus faecalis
Geographic Location: China
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
I440S	-	cyclic dinucleotide phosphodiesterase YybT, single resistance variant	Enterococcus faecalis	DAPTOMYCINDaptomycin	Card DatabaseReference Gene Catalog	Confirmed

Papers2

Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.

PMID 40775271 · 2025

The study identified the optrA gene as the primary mechanism of linezolid resistance in Enterococcus species from cancer patients in China, along with other resistance genes such as tet(M), erm(A), and erm(B).

Gene Information

Gene Name: yybT
Allele: YybT
Encodes: peptide permease
Source Database: Reslit
Organisms Tested In: • Enterococcus faecalis
Geographic Location: China
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA1241515

Browse AMR Genes

yybT

Mutations

Gene Information