yycI

two-component system regulator

Validation StatusCandidate

Overview

Mechanism: loss of function
Validation Method: whole-genome sequencing and proteomics
Drug Classes: Daptomycin, Vancomycin
Organisms: Staphylococcus aureus
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V13L	-	-	Staphylococcus aureus	Vancomycin	Reslit	Candidate

Papers2

Mutation in the Two-Component System Regulator YycH Leads to Daptomycin Tolerance in Methicillin-Resistant Staphylococcus aureus upon Evolution with a Population Bottleneck.

PMID 35913149 · 2022

Mutations in the yycH and yycI genes, which are regulators of the WalKR two-component system, lead to daptomycin tolerance in methicillin-resistant Staphylococcus aureus. These mutations result in the loss of function of the YycH and YycI proteins, downregulating the WalKR system and affecting cell wall metabolism, thus increasing tolerance to daptomycin and vancomycin.

Gene Information

Gene Name: yycI
Allele: yycI
Encodes: two-component system regulator
Source Database: Reslit
Mechanism: loss of function
Confers Resistance To: Daptomycin
Organisms Tested In: • Staphylococcus aureus
Validation Method: whole-genome sequencing and proteomics
Sequence Accession: PRJNA798197|PRJNA819400|PXD031078

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yycI

Mutations

Gene Information