zapA

Z-ring assembly factor

Validation StatusCandidate

Overview

Validation Method: MIC analysis and complementation tests
Drug Classes: Cefixime
Organisms: Salmonella enterica serovar Typhimurium, Neisseria gonorrhoeae
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
299ins	-	frameshift in zapA	Neisseria gonorrhoeae	Cefixime	Reslit	Candidate

Papers2

Evidence for Involvement of the Salmonella enterica Z-Ring Assembly Factors ZapA and ZapB in Resistance to Bile.

PMID 33717045 · 2021

The study identifies ZapA and ZapB as essential for bile resistance in Salmonella enterica serovar Typhimurium. Both genes are upregulated in response to bile, and their disruption leads to bile sensitivity. ZapB is degraded by the Lon protease in the presence of bile, and its stability is influenced by the Hfq chaperone and the sRNA MicA.

Gene Information

Gene Name: zapA
Allele: zapA
Encodes: Z-ring assembly factor
Source Database: Reslit
Organisms Tested In: • Salmonella enterica serovar Typhimurium
Validation Method: MIC analysis and complementation tests

Browse AMR Genes

zapA

Mutations

Gene Information