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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations mcr-3T277A

phosphoethanolamine transferase

Protein ChangeT277A

Nucleotide ChangeACC->GCC

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased MCR-3 function
Resistance To: Colistin
Organisms: Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Aeromonas veronii, Salmonella enterica
Papers: 1

Paper Information1

1

Molecular Insights into Functional Differences between mcr-3- and mcr-1-Mediated Colistin Resistance.

PMID 29987148 · 2018

Mutation Information

mcr-3: p.T277A / c.ACC->GCC

Protein Change: T277A
Nucleotide Change: ACC->GCC
Organisms: Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Aeromonas veronii, Salmonella enterica
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Colistin

Effect on Function

decreased MCR-3 function

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research