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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations clsD27N

Genecls

cardiolipin synthetase

Protein ChangeD27N

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene Catalog

Overview

Mechanism: cardiolipin synthase Cls, single resistance variant
Resistance To: DAPTOMYCIN, Daptomycin
Organisms: Enterococcus faecium
Papers: 1

Paper Information1

1

Emergence of daptomycin non-susceptibility in colonizing vancomycin-resistant Enterococcus faecium isolates during daptomycin therapy.

PMID 26454536 · 2015

cls

Enterococcus faecium cls conferring resistance to daptomycin; CARD accession: CARD:3003092

Mutation Information

Protein Change: D27N
Organisms: Enterococcus faecium
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

DAPTOMYCINDaptomycin

Effect on Function

cardiolipin synthase Cls; single resistance variant

Source Database

Reference Gene CatalogCard Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research