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Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Clofazimine Exposure In Vitro Selects Efflux Pump Mutants and Bedaquiline Resistance
Mutations in rv0678 lead to overexpression of the mmpL5-mmpS5 efflux pump, causing cross-resistance to bedaquiline and clofazimine.
Site-directed mutagenesis of Mycobacterium tuberculosis and functional validation to investigate potential bedaquiline resistance-causing mutations.
The atpE Ile66Val mutation did not elevate the MIC above the critical concentration (MIC 0.25–0.5 µg/ml), while the MIC of the Rv0678 Thr33Ala mutant strains (> 1.0 µg/ml) classifies the strain as resistant.
Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to bedaquiline; CARD accession: CARD:3007674
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