acrR
Overview
- Drug Classes
- Fluoroquinolone, Tigecycline, norfloxacin|ciprofloxacin, Norfloxacin, Ciprofloxacin
- Organisms
- Klebsiella pneumoniae, Escherichia coli
- Papers
- 4
- Mutations
- 29
| Nucleotide Change | Protein Change | Type | Effect on Function | Resistance To | Year | Paper | Status |
|---|---|---|---|---|---|---|---|
| - | F197I | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| - | A20T | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| - | G121* | - | - | Tigecycline | 2017 | Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment. PMID: 27219271 | Not Validated |
| - | E122K | - | - | Tigecycline | 2017 | Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment. PMID: 27219271 | Not Validated |
| - | L195V | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| - | M123* | - | - | Tigecycline | 2017 | Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment. PMID: 27219271 | Not Validated |
| - | L197L | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| - | P161R | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| - | G164A | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| - | F204L | - | - | Tigecycline | 2017 | Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates. PMID: 28533243 | Not Validated |
| - | R173G | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| - | A151V | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| - | K201M | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| - | G121V | - | - | Tigecycline | 2017 | Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment. PMID: 27219271 | Not Validated |
| - | F172S | - | - | Fluoroquinolone | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| A147C | K146T | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| A16T | I16F | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| A62T | I62F | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| A63G | K62R | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| C156T | P155L | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| C6A | T5N | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| del382CAGGCCCAGCGGCAG | - | - | - | Norfloxacin, Ciprofloxacin | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| del430ACCTTGAAAGAG | - | - | - | Norfloxacin, Ciprofloxacin | 2003 | Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. PMID: 12936981 | Not Validated |
| G125A | V125I | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| G79A | V79I | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| T202G | M201R | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| T24C | F24L | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| T25C | S25P | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
| T47G | C47G | - | - | norfloxacin|ciprofloxacin | 2003 | Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. PMID: 14506034 | Not Validated |
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- F197I
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- A20T
Confers Resistance To
Organisms Observed In
Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.
PMID 27219271 · 2017Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- G121*
Confers Resistance To
Organisms Observed In
Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.
PMID 27219271 · 2017Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- E122K
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- L195V
Confers Resistance To
Organisms Observed In
Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.
PMID 27219271 · 2017Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- M123*
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- L197L
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- P161R
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- G164A
Confers Resistance To
Organisms Observed In
Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
PMID 28533243 · 2017Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- F204L
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- R173G
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- A151V
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- K201M
Confers Resistance To
Organisms Observed In
Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.
PMID 27219271 · 2017Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- G121V
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Protein Change
- F172S
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- A147C
- Protein Change
- K146T
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- A16T
- Protein Change
- I16F
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- A62T
- Protein Change
- I62F
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- A63G
- Protein Change
- K62R
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- C156T
- Protein Change
- P155L
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- C6A
- Protein Change
- T5N
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- del382CAGGCCCAGCGGCAG
Confers Resistance To
Organisms Observed In
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
PMID 12936981 · 2003Under development. Phenotype should be used with caution.
Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- del430ACCTTGAAAGAG
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- G125A
- Protein Change
- V125I
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- G79A
- Protein Change
- V79I
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- T202G
- Protein Change
- M201R
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- T24C
- Protein Change
- F24L
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- T25C
- Protein Change
- S25P
Confers Resistance To
Organisms Observed In
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
PMID 14506034 · 2003Mutation Information
- Gene Name
- acrR
- Nucleotide Change
- T47G
- Protein Change
- C47G