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mexB

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
AMR Rules
Browse AMR rules for mexB
Validation StatusCandidate

Overview

Papers
1
Mutations
10

Mutations

Protein ChangeNucleotide ChangeMechanismOrganismResistance ToDatabaseValidation Status
D408K-loss of activityPseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
K939A-loss of activityPseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
K939E-loss of activityPseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
K939D-loss of activityPseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
D408A-loss of activityPseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
K939R-preserved resistancePseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
D407E-loss of activityPseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
D407A-loss of activityPseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
D407K-loss of activityPseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
D408E-loss of activityPseudomonas aeruginosa
aztreonam|novobiocin
Reslit
Candidate
Papers1
1

Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa.

PMID 11160105 · 2001

Mutations in charged residues of transmembrane segments of MexB affect efflux pump function.

Mutation Information

mexB: p.D408KmexB: p.K939AmexB: p.K939EmexB: p.K939DmexB: p.D408AmexB: p.K939RmexB: p.D407EmexB: p.D407AmexB: p.D407KmexB: p.D408E
Protein Change
D408K, K939A, K939E, K939D, D408A, K939R, D407E, D407A, D407K, D408E
Organisms
Pseudomonas aeruginosa
Confers Resistance To
aztreonam|novobiocin
Effect on Function
loss of activity; preserved resistance
Source Database
Reslit