ResLit

ramR

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
Curation StatusNot Validated

Overview

Drug Classes
Tigecycline, ciprofloxacin
Organisms
Klebsiella pneumoniae, Salmonella enterica
Papers
3
Mutations
16
Mutations16
Nucleotide ChangeProtein ChangeTypeEffect on FunctionResistance ToYearPaperStatus
-L111R--
Tigecycline
2017

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID: 28533243
Not Validated
-G25A--
ciprofloxacin
2009

Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of ramA and other global regulators.

PMID: 19104017
Not Validated
-E113K--
Tigecycline
2017

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID: 28533243
Not Validated
-Q122*--
Tigecycline
2017

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID: 28533243
Not Validated
-Q135*--
Tigecycline
2017

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID: 28533243
Not Validated
-E190*--
Tigecycline
2017

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID: 27219271
Not Validated
-*195K--
Tigecycline
2017

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID: 28533243
Not Validated
-L156V--
Tigecycline
2017

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID: 27219271
Not Validated
-I177T--
Tigecycline
2017

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID: 27219271
Not Validated
-F181*--
Tigecycline
2017

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID: 27219271
Not Validated
-A193S--
Tigecycline
2017

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID: 27219271
Not Validated
-H103Q--
Tigecycline
2017

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID: 27219271
Not Validated
-A178D--
Tigecycline
2017

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID: 27219271
Not Validated
-L44R--
Tigecycline
2017

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID: 28533243
Not Validated
-E175D--
Tigecycline
2017

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID: 27219271
Not Validated
-A19V--
Tigecycline
2017

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID: 28533243
Not Validated
Papers3
1

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID 28533243 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
L111R

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
2

Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of ramA and other global regulators.

PMID 19104017 · 2009

Mutation in 5408-cip.

Mutation Information

Gene Name
ramR
Protein Change
G25A

Confers Resistance To

ciprofloxacin

Organisms Observed In

• Salmonella enterica
3

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID 28533243 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
E113K

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
4

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID 28533243 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
Q122*

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
5

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID 28533243 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
Q135*

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
6

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID 27219271 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
E190*

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
7

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID 28533243 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
*195K

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
8

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID 27219271 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
L156V

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
9

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID 27219271 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
I177T

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
10

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID 27219271 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
F181*

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
11

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID 27219271 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
A193S

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
12

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID 27219271 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
H103Q

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
13

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID 27219271 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
A178D

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
14

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID 28533243 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
L44R

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
15

Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.

PMID 27219271 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
E175D

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae
16

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

PMID 28533243 · 2017

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
ramR
Protein Change
A19V

Confers Resistance To

Tigecycline

Organisms Observed In

• Klebsiella pneumoniae