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Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa.

PMID: 111601052001

Key Findings

Mutations in charged residues of transmembrane segments of MexB affect efflux pump function.

0gene entries

10mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mexB	D408A	-	loss of activity	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-
mexB	K939R	-	preserved resistance	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-
mexB	D407E	-	loss of activity	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-
mexB	D408K	-	loss of activity	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-
mexB	D407A	-	loss of activity	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-
mexB	K939A	-	loss of activity	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-
mexB	D407K	-	loss of activity	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-
mexB	K939E	-	loss of activity	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-
mexB	D408E	-	loss of activity	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-
mexB	K939D	-	loss of activity	Pseudomonas aeruginosa	Aztreonam\|Novobiocin	Reslit	-