Systematic Analysis of a Conserved Region of the Aminoglycoside 6′-N-Acetyltransferase Type Ib

PMID: 117092992001

Key Findings

The study identifies key residues in the aac(6')-Ib gene that are crucial for resistance to kanamycin and amikacin, highlighting the importance of motif B in substrate specificity and enzymatic activity.

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1gene entry

10mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
aac(6')-Ib	1	aminoglycoside 6'-N-acetyltransferase	KanamycinAmikacin	Escherichia coli	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
aac(6')-Ib	P157A	-	-	E. coli	Kanamycin\|Amikacin	Reslit	-
aac(6')-Ib	I163A	-	-	E. coli	Kanamycin\|Amikacin	Reslit	-
aac(6')-Ib	P155A	-	-	E. coli	Kanamycin\|Amikacin	Reslit

Browse Papers

Systematic Analysis of a Conserved Region of the Aminoglycoside 6′-N-Acetyltransferase Type Ib

AMR Genes

AMR Mutations