X-ray structure of the AAC(6′)-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members.

PMID: 125920132003

Key Findings

The study reports the high-resolution structure of the aminoglycoside acetyltransferase AAC(6′)-Ii in complex with coenzyme A, providing insights into its structure and mechanism of action in conferring resistance to aminoglycoside antibiotics such as kanamycin and gentamicin.

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1gene entry

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
aac(6')-I	1	aminoglycoside acetyltransferase	KanamycinGentamicin	Enterococcus faecium	Reslit	-

Browse Papers

X-ray structure of the AAC(6′)-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members.

AMR Genes