High-level expression of ampC beta-lactamase due to insertion of nucleotides between -10 and -35 promoter sequences in Escherichia coli clinical isolates: cases not responsive to extended-spectrum-cephalosporin treatment.

PMID: 128214592003Taiwan

Key Findings

The study identifies mutations in the ampC promoter region leading to high-level expression of the AmpC beta-lactamase in E. coli clinical isolates, causing resistance to extended-spectrum cephalosporins.

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1gene entry

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
ampC	1	beta-lactamase	CefoxitinCefazolinAmpicillinCefotaximeCeftazidimeCeftriaxone	Escherichia coli	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ampC	-	C58T	-	Escherichia coli	Cefoxitin\|Cefazolin\|Ampicillin\|Cefotaxime\|Ceftazidime\|Ceftriaxone	Reslit	-
ampC	-	G-28A	-	Escherichia coli	Cefoxitin\|Cefazolin\|Ampicillin\|Cefotaxime\|Ceftazidime\|Ceftriaxone	Reslit	-

Browse Papers

High-level expression of ampC beta-lactamase due to insertion of nucleotides between -10 and -35 promoter sequences in Escherichia coli clinical isolates: cases not responsive to extended-spectrum-cephalosporin treatment.

AMR Genes

AMR Mutations