A functional dlt operon, encoding proteins required for incorporation of d-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae.

PMID: 168854472006

Key Findings

The dlt operon in Streptococcus pneumoniae confers resistance to cationic antimicrobial peptides such as nisin and gallidermin through the incorporation of d-alanine into teichoic acids.

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1gene entry

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
dltA	1	d-alanine- d-alanyl carrier protein ligase (Dcl)	-	Streptococcus pneumoniae	Reslit	-

Browse Papers

A functional dlt operon, encoding proteins required for incorporation of d-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae.

AMR Genes