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Key Findings
The study identified nfxB mutations as a key mechanism for azithromycin resistance in Pseudomonas aeruginosa biofilms, leading to hyperexpression of the MexCD-OprJ efflux pump and cross-resistance to ciprofloxacin and cefepime.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| nfxB | 1 | negative regulator of MexCD-OprJ efflux pump | AzithromycinCiprofloxacinCefepime |
| Reslit | - |
Reslit |
| - |
| A30V | - | - | Pseudomonas aeruginosa | Azithromycin|Ciprofloxacin|Cefepime | Reslit | - |
| L178P | - | - | Pseudomonas aeruginosa | Azithromycin|Ciprofloxacin|Cefepime | Reslit | - |
| L26P | - | - | Pseudomonas aeruginosa | Azithromycin|Ciprofloxacin|Cefepime | Reslit | - |
| L127P | - | - | Pseudomonas aeruginosa | Azithromycin|Ciprofloxacin|Cefepime | Reslit | - |
| G180D | - | - | Pseudomonas aeruginosa | Azithromycin|Ciprofloxacin|Cefepime | Reslit | - |
| R42L | - | - | Pseudomonas aeruginosa | Azithromycin|Ciprofloxacin|Cefepime | Reslit | - |
| L29P | - | - | Pseudomonas aeruginosa | Azithromycin|Ciprofloxacin|Cefepime | Reslit | - |
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