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The pmrCAB Operon Mediates Polymyxin Resistance in Acinetobacter baumannii ATCC 17978 and Clinical Isolates through Phosphoethanolamine Modification of Lipid A.

PMID: 216464822011

Key Findings

Mutations in the pmrB gene contribute to polymyxin resistance in A. baumannii.

0gene entries

15mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrB	R263P	-	-	Acinetobacter baumannii	Polymyxin b	Reslit	-
pmrB	A211V	-	-	Acinetobacter baumannii	Polymyxin b	Reslit	-
pmrB	Q277H	-	-	Acinetobacter baumannii	Polymyxin b	Reslit	-
pmrB	F90L	-	-	Acinetobacter baumannii	Polymyxin b	Reslit	-
pmrB	M12I	-	-	Acinetobacter baumannii	Polymyxin b	Reslit	-
pmrB	P360Q	-	-	Acinetobacter baumannii	Polymyxin b	Reslit	-
pmrB	T235I	-	-	Acinetobacter baumannii	Polymyxin b	Reslit	-
pmrB	R231L	-	two-component system sensor histidine kinase PmrB	Acinetobacter baumannii	Polymyxin bCOLISTIN	ReslitReference Gene Catalog	-
pmrA	M12I	-	The mutation in pmrA (M12I) leads to constitutive activation of the PmrAB two-component system, resulting in increased expression of the pmrCAB operon and resistance to polymyxin B., two-component system response regulator PmrA	Acinetobacter baumannii	Polymyxin bCOLISTIN	ReslitReference Gene Catalog	-
pmrB	G315D	-	two-component system sensor histidine kinase PmrB	Acinetobacter baumannii	Polymyxin bCOLISTIN	ReslitReference Gene Catalog	-
pmrB	T7I	-	-	Acinetobacter baumannii	Polymyxin b	Reslit	-
pmrA	H499R	-	The mutation in pmrA (H499R) leads to constitutive activation of the PmrAB two-component system, resulting in increased expression of the pmrCAB operon and resistance to polymyxin B.	Acinetobacter baumannii	Polymyxin b	Reslit	-