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PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients.

PMID: 221062242012

Key Findings

Multiple pmrB mutations were identified in clinical isolates, including single and double missense mutations in the periplasmic and DHP domains.

0gene entries

33mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrB	A95T	-	gain-of-function	Pseudomonas aeruginosa	Colistin	Reslit	-
pmrB	R259H	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	A248V	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	A248T	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	T253M	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	R135Q	-	gain-of-function	Pseudomonas aeruginosa	Colistin	Reslit	-
pmrB	S257N	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	A54V	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	M292I	-	gain-of-function	Pseudomonas aeruginosa	Colistin	Reslit	-
pmrB	R57H	-	gain-of-function	Pseudomonas aeruginosa	Colistin	Reslit	-
pmrB	G52D	-	gain-of-function	Pseudomonas aeruginosa	Polymyxin b	Reslit	-
pmrB	L14P	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	G188D	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	R79H	-	gain-of-function	Pseudomonas aeruginosa	Colistin	Reslit	-
pmrB	P456S	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	L243Q	-	gain-of-function, two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	ColistinCOLISTIN	ReslitReference Gene Catalog	-
pmrB	A247T	-	two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	COLISTIN	Reference Gene Catalog	-
pmrB	D47del	-	two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	COLISTIN	Reference Gene Catalog	-
pmrB	S257D	-	two-component system sensor histidine kinase PmrB	Pseudomonas aeruginosa	COLISTIN	Reference Gene Catalog	-