Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis.

PMID: 229042822012

Key Findings

Mutations in CarD that weaken its interaction with RNAP β1 increase sensitivity to rifampin.

0gene entries

4mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
carD	R25E	-	weakens interaction with RNAP	Mycobacterium tuberculosis, Mycobacterium smegmatis	Rifampin	Reslit	-
carD	R47E	-	weakens interaction with RNAP	Mycobacterium smegmatis, Mycobacterium tuberculosis	Rifampin	Reslit	-