Characterization of the new AmpC beta-lactamase FOX-8 reveals a single mutation, Phe313Leu, located in the R2 loop that affects ceftazidime hydrolysis.

PMID: 238776922013Spain

Key Findings

The study identifies FOX-8, a novel AmpC beta-lactamase with a Phe313Leu mutation in the R2 loop that reduces ceftazidime hydrolysis compared to FOX-3.

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2gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaFOX	1	beta-lactamase	CeftazidimeTICARCILLINAMOXICILLINCEFOXITINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIME+3 more	Escherichia coli	ResFinder DatabaseReslit	-

Browse Papers

Characterization of the new AmpC beta-lactamase FOX-8 reveals a single mutation, Phe313Leu, located in the R2 loop that affects ceftazidime hydrolysis.

AMR Genes