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Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays.

PMID: 277892872016

Key Findings

mutations in distal binding pocket of AcrB affect efflux of substrates

0gene entries

8mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
acrB	F178A	-	-	Escherichia coli	Macrolide\|Fluoroquinolones	Reslit	-
acrB	F615A	-	-	Escherichia coli	Macrolide\|Fluoroquinolones	Reslit	-
acrB	I278A	-	-	Escherichia coli	Macrolide\|Fluoroquinolones	Reslit	-
acrB	I626A	-	-	Escherichia coli	Macrolide\|Fluoroquinolones	Reslit	-
acrB	F610A	-	-	Escherichia coli	Macrolide\|Fluoroquinolones	Reslit	-
acrB	F628A	-	-	Escherichia coli	Macrolide\|Fluoroquinolones	Reslit	-
acrB	F617A	-	-	Escherichia coli	Macrolide\|Fluoroquinolones	Reslit	-
acrB	F136A	-	-	Escherichia coli	Macrolide\|Fluoroquinolones	Reslit	-