Discovery of 1-Hydroxypyridine-2(1H)-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor.

PMID: 284821432017

Key Findings

The study identified 1-hydroxypyridine-2(1H)-thione-6-carboxylic acid (compound 3) as a potent inhibitor of the VIM2 metallo-beta-lactamase, restoring amoxicillin activity against VIM2-producing E. coli.

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1gene entry

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blavim2	1	metallo-beta-lactamase	Carbapenem	Pseudomonas aeruginosa Escherichia coli	Reslit	-

Browse Papers

Discovery of 1-Hydroxypyridine-2(1H)-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor.

AMR Genes