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Explore scientific publications on antimicrobial resistance
Explore scientific publications on antimicrobial resistance
Key Findings
The study identifies CmrA as a novel transcriptional regulator that induces the expression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa in response to electrophilic stress. It also characterizes PA2048, a quinol monooxygenase, as a key component in the activation of the efflux pump.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| cmrA | 1 | transcriptional regulator | ChloramphenicolFluoroquinoloneTrimethoprim |
| Reslit | - |
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| A68V | - | AraC family transcriptional regulator CmrA | Pseudomonas aeruginosa | CHLORAMPHENICOL/IMIPENEM/QUINOLONE | Reference Gene Catalog | - | |
| N214K | - | AraC family transcriptional regulator CmrA | Pseudomonas aeruginosa | CHLORAMPHENICOL/IMIPENEM/QUINOLONE | Reference Gene Catalog | - | |
| L89Q | - | AraC family transcriptional regulator CmrA | Pseudomonas aeruginosa |
Reference Gene Catalog |
| - |
| H204L | - | AraC family transcriptional regulator CmrA | Pseudomonas aeruginosa | CHLORAMPHENICOL/IMIPENEM/QUINOLONE | Reference Gene Catalog | - |
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