2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

PMID: 287499492017

Key Findings

The study identified that 2-aminoimidazole compounds enhance the effectiveness of β-lactam antibiotics against Mycobacterium tuberculosis by reducing β-lactamase secretion and increasing cell envelope permeability. The β-lactamase gene blaC was found to contribute to intrinsic resistance.

View on PubMed

1gene entry

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaC	1	beta-lactamase	AmpicillinOxacillinPenicillinAmoxicillinCefotaximeCeftazidimeCefoxitinMeropenem	Mycobacterium tuberculosis	Reslit	-

Browse Papers

2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

AMR Genes