Structural and Functional Analysis of the AdeB Multidrug Efflux Pump in Acinetobacter baumannii

PMID: 348242292023

Key Findings

Mutations in the deep-binding pocket of AdeB affect resistance to various antibiotics

1gene entry

4mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
adeB	1	Multidrug efflux pump	ChloramphenicolLevofloxacin	Acinetobacter baumannii Escherichia coli	Reslit	-

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
adeB	W610F	-	increased resistance	E. coli	Chloramphenicol\|Levofloxacin	Reslit	-
adeB	T605F	-	increased resistance	E. coli	Chloramphenicol\|Levofloxacin	Reslit	-
adeB	Q292K	-	increased resistance	E. coli	Chloramphenicol\|Levofloxacin