Key Findings

The study identifies HprSR as a two-component system in E. coli that senses reactive chlorine species (RCS) such as HOCl and N-chlorotaurine (N-ChT). The system regulates the expression of the msrPQ operon, which encodes the periplasmic methionine sulfoxide reductase (MsrPQ) involved in repairing HOCl-oxidized proteins.