Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling.

PMID: 376952982023

0gene entries

5mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ampC	G183D	-	-	Pseudomonas aeruginosa	ImipenemCeftolozane/tazobactam	Reslit	-
ampD	H157Y	-	increased basal ampC expression, 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	Pseudomonas aeruginosa	Ceftolozane/tazobactamImipenemCEPHALOSPORIN/TAZOBACTAM	ReslitReference Gene Catalog	-