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Clostridioides difficile MreE (PBP2) variants facilitate clinical disease during cephalosporin exposures.

PMID: 379612512023

Key Findings

mutations in mreE confer resistance to beta-lactam antibiotics

0gene entries

16mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mreE	V497L	-	penicillin-binding protein MreE	Clostridioides difficile	Ampicillin\|Ceftriaxone\|Cefoxitin\|Cephalexin\|Cefoperazone\|CefepimeCEPHALOSPORIN	ReslitReference Gene Catalog	-
mreE	A795V	-	penicillin-binding protein MreE	Clostridioides difficile	Ampicillin\|Ceftriaxone\|Cefoxitin\|Cephalexin\|Cefoperazone\|CefepimeCEPHALOSPORIN	ReslitReference Gene Catalog	-
mreE	A694V	-	penicillin-binding protein MreE	Clostridioides difficile	Ampicillin\|Ceftriaxone\|Cefoxitin\|Cephalexin\|Cefoperazone\|CefepimeCEPHALOSPORIN	ReslitReference Gene Catalog	-
mreE	Y721S	-	penicillin-binding protein MreE	Clostridioides difficile	Ampicillin\|Ceftriaxone\|Cefoxitin\|Cephalexin\|Cefoperazone\|CefepimeCEPHALOSPORIN	ReslitReference Gene Catalog	-
mreE	A778V	-	penicillin-binding protein MreE	Clostridioides difficile	Ampicillin\|Ceftriaxone\|Cefoxitin\|Cephalexin\|Cefoperazone\|CefepimeCEPHALOSPORIN	ReslitReference Gene Catalog	-
mreE	M496V	-	penicillin-binding protein MreE	Clostridioides difficile	Ampicillin\|Ceftriaxone\|Cefoxitin\|Cephalexin\|Cefoperazone\|CefepimeCEPHALOSPORIN	ReslitReference Gene Catalog	-
mreE	Y721C	-	penicillin-binding protein MreE	Clostridioides difficile	Ampicillin\|Ceftriaxone\|Cefoxitin\|Cephalexin\|Cefoperazone\|CefepimeCEPHALOSPORIN	ReslitReference Gene Catalog	-
mreE	A795L	-	penicillin-binding protein MreE	Clostridioides difficile	CEPHALOSPORIN	Reference Gene Catalog	-
mreE	A694T	-	penicillin-binding protein MreE	Clostridioides difficile	CEPHALOSPORIN	Reference Gene Catalog	-