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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system.

PMID: 397045022025

Key Findings

Mutations in VapB affect plasmid stability and antibiotic tolerance through enhanced cleavage by Lon protease.

0gene entries

6mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
vapB	A13P	-	enhanced cleavage by Lon protease	Escherichia coli	Beta-lactam	Reslit	-
vapB	L16R	-	enhanced cleavage by Lon protease	Escherichia coli	Beta-lactam	Reslit	-
vapB	V20G	-	enhanced cleavage by Lon protease	Escherichia coli	Beta-lactam	Reslit	-
vapB	T3N	-	enhanced cleavage by Lon protease	Escherichia coli	Beta-lactam	Reslit	-
vapB	V5E	-	enhanced cleavage by Lon protease	Escherichia coli	Beta-lactam	Reslit	-
vapB	L7P	-	enhanced cleavage by Lon protease	Escherichia coli	Beta-lactam	Reslit	-