Outer membrane permeability of Pseudomonas aeruginosa through β-lactams: new evidence on the role of OprD and OpdP porins in antibiotic resistance.

PMID: 400355752025

Key Findings

The study identifies mutations in the oprD gene that lead to reduced OprD expression and carbapenem resistance in Pseudomonas aeruginosa. The role of OprD and OpdP porins in carbapenem permeability is highlighted.

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1gene entry

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
oprD	1	outer membrane porin	Carbapenem	Pseudomonas aeruginosa	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
oprD	-	G1017A	results in the synthesis of a truncated porin	Pseudomonas aeruginosa	Carbapenem	Reslit	-
oprD	L434P	T1301C	increases the instability of the porin	Pseudomonas aeruginosa	Carbapenem	Reslit	-

Browse Papers

Outer membrane permeability of Pseudomonas aeruginosa through β-lactams: new evidence on the role of OprD and OpdP porins in antibiotic resistance.

AMR Genes

AMR Mutations