Mechanisms of Carbapenem Resistance in Clinical Isolates of Carbapenem-Resistant Pseudomonas aeruginosa (CRPA)

PMID: 402409922023

Key Findings

The study identifies oprD mutations and structural disruptions as the primary mechanisms of carbapenem resistance in CROPA strains, with wild-type oprD restoration reversing resistance.

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1gene entry

3mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
oprD	1	outer membrane porin	ImipenemMeropenem	Pseudomonas aeruginosa	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
oprD	V126E	-	-	-	Imipenem\|Meropenem	Reslit	-
oprD	G71E	-	-	-	Imipenem\|Meropenem	Reslit	-
oprD	S209R	-	-	-	Imipenem\|Meropenem	Reslit	-

Browse Papers

Mechanisms of Carbapenem Resistance in Clinical Isolates of Carbapenem-Resistant Pseudomonas aeruginosa (CRPA)

AMR Genes

AMR Mutations