Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase.

PMID: 404910392025

Key Findings

The E112K mutation in prs is associated with reduced PRPP synthetase activity and contributes to the growth defects and tolerance phenotype of COL.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
prs	E112K	-	reduces catalytic activity	Staphylococcus aureus	Ciprofloxacin\|Daptomycin	Reslit	-