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Collateral sensitivity and cross-resistance in six species of bacteria exposed to six classes of antibiotics.

PMID: 405398052025

Key Findings

Mutations in domain IV of fusA are responsible for kanamycin resistance in five bacterial species.

0gene entries

90mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
fusA	A608V	-	-	Enterococcus faecalis, Salmonella enterica, Staphylococcus aureus, Yersinia enterocolitica, Acinetobacter pittii, Bacillus subtilis	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	F601V	-	-	Bacillus subtilis, Salmonella enterica, Staphylococcus aureus, Yersinia enterocolitica, Enterococcus faecalis, Acinetobacter pittii	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	T668A	-	-	Enterococcus faecalis, Bacillus subtilis, Salmonella enterica, Staphylococcus aureus, Acinetobacter pittii, Yersinia enterocolitica	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	F605V	-	-	Acinetobacter pittii, Enterococcus faecalis, Bacillus subtilis, Yersinia enterocolitica, Salmonella enterica, Staphylococcus aureus	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	A493G	-	-	Yersinia enterocolitica, Acinetobacter pittii, Enterococcus faecalis, Salmonella enterica, Staphylococcus aureus, Bacillus subtilis	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	S589A	-	-	Salmonella enterica, Staphylococcus aureus, Yersinia enterocolitica, Acinetobacter pittii, Bacillus subtilis, Enterococcus faecalis	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	A590V	-	-	Bacillus subtilis, Salmonella enterica, Staphylococcus aureus, Yersinia enterocolitica, Enterococcus faecalis, Acinetobacter pittii	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	G148C	-	-	Enterococcus faecalis, Bacillus subtilis, Salmonella enterica, Staphylococcus aureus, Acinetobacter pittii, Yersinia enterocolitica	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	A595V	-	-	Acinetobacter pittii, Enterococcus faecalis, Bacillus subtilis, Yersinia enterocolitica, Salmonella enterica, Staphylococcus aureus	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	G665C	-	-	Yersinia enterocolitica, Acinetobacter pittii, Enterococcus faecalis, Salmonella enterica, Staphylococcus aureus, Bacillus subtilis	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	A539E	-	-	Salmonella enterica, Staphylococcus aureus, Yersinia enterocolitica, Acinetobacter pittii, Enterococcus faecalis	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	V86A	-	-	Bacillus subtilis, Salmonella enterica, Staphylococcus aureus, Yersinia enterocolitica, Enterococcus faecalis, Acinetobacter pittii	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	G551C	-	-	Enterococcus faecalis, Bacillus subtilis, Salmonella enterica, Staphylococcus aureus, Acinetobacter pittii, Yersinia enterocolitica	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	G507S	-	-	Acinetobacter pittii, Enterococcus faecalis, Bacillus subtilis, Yersinia enterocolitica, Salmonella enterica, Staphylococcus aureus	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-
fusA	A580V	-	-	Yersinia enterocolitica, Acinetobacter pittii, Enterococcus faecalis, Salmonella enterica, Staphylococcus aureus, Bacillus subtilis	Kanamycin\|Tobramycin\|Gentamicin	Reslit	-