Mechanistic and Biophysical Characterization of Polymyxin Resistance Response Regulator PmrA in Acinetobacter baumannii

PMID: 413042842024

Key Findings

Mutations in the receiver domain of PmrA were shown to increase colistin resistance in A. baumannii.

0gene entries

4mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrA	P102R	C306G	altered phosphorylation	Acinetobacter baumannii	Colistin	Reslit	-
pmrA	I13M	C40G	slowed phosphorylation	Acinetobacter baumannii	Colistin	Reslit	-
pmrA	D10N	G30A	disrupted phosphorylation	Acinetobacter baumannii	Colistin	Reslit	-
pmrA	G54E	GGT->GAG	altered phosphorylation	Acinetobacter baumannii	Colistin	Reslit	-