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Deciphering the emergence of mutations in Pseudomonas aeruginosa after ceftolozane/tazobactam treatment and evaluating therapeutic alternatives.

PMID: 413617472025

Key Findings

Mutations in ampC lead to increased resistance to ceftolozane/tazobactam.

0gene entries

6mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ampC	T70I	-	-	Pseudomonas aeruginosa	Ceftolozane/tazobactam	Reslit	-
ampC	G157D	-	-	Pseudomonas aeruginosa	Ceftolozane/tazobactam	Reslit	-
ampC	P217Q	-	-	Pseudomonas aeruginosa	Ceftolozane/tazobactam	Reslit	-
ampC	F121L	-	-	Pseudomonas aeruginosa	Ceftolozane/tazobactam	Reslit	-
ampC	P154L	-	-	Pseudomonas aeruginosa	Ceftolozane/tazobactam	Reslit	-
ampC	E221K	-	-	Pseudomonas aeruginosa	Ceftolozane/tazobactam	Reslit	-