Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
alanine racemase
Overview
| - |
| destabilizing |
| Mycobacterium tuberculosis |
Cycloserine |
Reslit |
| Candidate |
| F4L | - | - | - | Cycloserine | Reslit | Candidate |
| D344N | - | - | Mycobacterium tuberculosis | D-cycloserine | Reslit | Candidate |
| L283P | - | - | - | Cycloserine | Reslit | Candidate |
| Y388D | - | - | - | CycloserineD-cycloserine | Reslit | Supported |
| T20M | - | destabilizing | Mycobacterium tuberculosis | Cycloserine | Reslit | Candidate |
| R243S | - | destabilizing | Mycobacterium tuberculosis | Cycloserine | Reslit | Candidate |
| D322N | - | decreased affinity for DCS | Mycobacterium tuberculosis | D-cycloserine | Reslit | Candidate |
| Y388C | - | - | - | D-cycloserine | Reslit | Candidate |
| - | - | Mycobacterium tuberculosis | D-cycloserine | Reslit | Candidate |
| - | - | - | Cycloserine | Reslit | Candidate |
| - | - | - | Cycloserine | Reslit | Candidate |
| - | - | Mycobacterium tuberculosis | Cycloserine | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| alr | Reslit | 8 | Para-aminosalicylic acid, D-cycloserine +1 | Mycobacterium tuberculosis +5 | Belarus|South Africa|South Korea|India, South Africa, Brazil|Mato Grosso, Egypt, Brazil|United Kingdom | 2018, 2019, 2020, 2022, 2023, 2024 | AL123456 | - |
| Mtub_alr_DCS | Card Database | 1 | - | Mycobacterium tuberculosis H37Rv | - | - | NC_000962.3 | NP_217940.1 |
Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.
The study identifies 33 known AMR genes and 24 new genetic signatures of AMR in Mycobacterium tuberculosis using machine learning and structural analysis. It also reveals 97 epistatic interactions across 10 resistance classes and provides mechanistic insights into the selection of these genes.
Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes.
This study identifies alr overexpression and a promoter mutation as mechanisms of D-cycloserine resistance in Mycobacterium tuberculosis, along with a D322N missense mutation in the alr gene that reduces DCS inhibition.
A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic.
The study identifies multiple AMR genes and mutations associated with ethionamide, streptomycin, isoniazid, ethambutol, pyrazinamide, rifampicin, fluoroquinolones, terizidone, cycloserine, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis strains.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.
The study identified multiple AMR genes and mutations in Mycobacterium tuberculosis variant bovis strains from Mato Grosso, Brazil, including resistance to pyrazinamide, isoniazid, rifampicin, streptomycin, ethambutol, ethionamide, fluoroquinolones, kanamycin, capreomycin, paraminosalicylic acid, cycloserine, bedaquiline, linezolid, and delamanid.
Selection of Multi-Drug Targets against Drug-Resistant Mycobacterium tuberculosis XDR1219 Using the Hyperbolic Mapping of the Protein Interaction Network.
The study identifies several drug targets (DTs) in Mycobacterium tuberculosis XDR1219 using hyperbolic mapping of the protein interaction network. Key DTs include rpsA, rpsL, embB, embA, fbiC, fbiB, rpoB, dnaK, rpoA, rpoC, rpoZ, ddl, alr, pbpB, rplD, rplC, rmlC, Isr2, tlyA, pknB, dprE1, fas, accD1, accE5, Rv0200, galE3, pks5, msl3, phoP, dacB2, pknI, echA19, ltp3, and Rv3520c, which are involved in various metabolic pathways and are targeted by different antibiotics.
Draft genome sequence of novel Candidatus Ornithobacterium hominis carrying antimicrobial resistance genes in Egypt.
The study presents the draft genome sequence of Candidatus Ornithobacterium hominis, highlighting the presence of multiple antimicrobial resistance genes, including those conferring resistance to sulfonamides, aminoglycosides, fluoroquinolones, and others. Key genes identified include oxyR, gidB, murA, rpoB, gyrA, and others, which were experimentally validated for their resistance mechanisms.
AMR mechanisms in L. interrogans serovars: a comprehensive study.
The study identified 32 AMR genes in Leptospira interrogans serovars, with 20 key genes consistently present across most strains. Unique efflux pump systems were found in serovar Pomona, suggesting distinct resistance mechanisms.
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