Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside O-phosphotransferase APH(2'')-IIa
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| M85Y | - | - | Escherichia coli | Kanamycin|Gentamicin|Tobramycin|Sisomicin|Netilmicin|Dibekacin | Reslit | Candidate |
Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium.
Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium.
Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium.
Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium.
Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium.
The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'' )-IIa] provide insights into substrate selectivity in the APH(2'' ) subfamily.
The study characterizes the APH(2'')-IIa enzyme, which confers resistance to gentamicin and kanamycin by phosphorylating the 2''-hydroxyl group of these aminoglycosides. The crystal structures of the enzyme in complex with gentamicin and AMPPCP-streptomycin provide insights into its substrate selectivity.
Bulky "gatekeeper" residue changes the cosubstrate specificity of aminoglycoside 2"-phosphotransferase IIa.
The study identifies that the M85Y mutation in APH(2")-IIa alters the cosubstrate specificity, reducing ATP affinity and increasing GTP affinity, thereby affecting antibiotic resistance profiles.
Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation.
Probiotic supplementation in preterm infants reduces the diversity and persistence of antibiotic resistance genes in the gut microbiome, particularly targeting aminoglycoside, beta-lactam, tetracycline, and streptogramin resistance genes.
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).
The study found no significant increase in clinically relevant antimicrobial resistance gene burden in critically ill children treated with SDD-enhanced infection control compared to standard care.
No comments yet. Be the first to comment!
© 2026 ResLit. Data sourced from PubMed literature analysis.
Built for antimicrobial resistance research