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Browse Mutations aph(2'')-IIaM85Y

Geneaph(2'')-IIa

aminoglycoside-2''-phosphotransferase

Protein ChangeM85Y

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Kanamycin|Gentamicin|Tobramycin|Sisomicin|Netilmicin|Dibekacin
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Bulky "gatekeeper" residue changes the cosubstrate specificity of aminoglycoside 2"-phosphotransferase IIa.

PMID 23716051 · 2013

mutation affects cosubstrate specificity

Mutation Information

aph(2'')-IIa: p.M85Y

Protein Change: M85Y
Organisms: Escherichia coli
Confers Resistance To: Kanamycin|Gentamicin|Tobramycin|Sisomicin|Netilmicin|Dibekacin

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

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Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research