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baeS

sensor kinase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to baeS

Browse AMR rules for baeS

Validation StatusSupported

Overview

Mechanism: mutation in baeS leads to decreased susceptibility to LYS228
Validation Method: RT-PCR and qRT-PCR
Drug Classes: Tigecycline, Cefiderocol, Gentamicin, Aminoglycoside, Aminocoumarin, Carbapenem, CEFIDEROCOL, AZTREONAM/TEMOCILLIN/TICARCILLIN, TEMOCILLIN, AZTREONAM-AVIBACTAM, CEFTIBUTEN/CEFTIBUTEN-AVIBACTAM, AZTREONAM/AZTREONAM-AVIBACTAM
Organisms: Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Streptococcus equi subsp. equi, Enterobacter cloacae, Enterobacter asburiae
Geographic Location: China, South Africa
Alleles: 4
Papers: 18
Databases: Reslit
Mutations: 17

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
D89V	-	single resistance variant, two-component system sensor histidine kinase BaeS	Enterobacter cloacae, Acinetobacter baumannii	CEFIDEROCOL	Card DatabaseReference Gene Catalog	Confirmed
D181N	-	-	Klebsiella pneumoniae	Cefiderocol	Reslit	Candidate
S471N	-	-	Acinetobacter baumannii

Allele Variants4

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
baeS	Reslit	5	Tigecycline, Cefiderocol +2	Acinetobacter baumannii +2	South Africa	2014, 2018, 2023, 2024	MH697720\|MH697721\|MH697722\|MH697723\|MH697724\|MH697725\|MH697726\|MH697727\|MH697728	-
baes	Reslit	1	Gentamicin	Streptococcus equi subsp. equi	China	2023	CP133957\|CP133955\|CP133956	-
BaeS	Reslit	1	Cefiderocol	Acinetobacter baumannii	-	2023	-	-
bae S	Reslit	1	Carbapenem	Acinetobacter baumannii	-	2024	MK344183.1\|MK344168.1	-

Papers18

1

Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility.

PMID 24885279 · 2014

The BaeSR two-component system regulates the expression of the AdeAB efflux pump genes in Acinetobacter baumannii, thereby influencing tigecycline susceptibility.

Gene Information

Gene Name: baeS
Allele: baeS
Encodes: sensor kinase
Source Database: Reslit
Confers Resistance To: Tigecycline
Organisms Tested In: • Acinetobacter baumannii
Validation Method: RT-PCR and qRT-PCR

2

Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae.

PMID 30061293 · 2018

The study identifies mutations in baeS, cpxA, ftsI, and baeR that decrease susceptibility to LYS228 in Escherichia coli and Klebsiella pneumoniae. These mutations are linked to efflux pump activation and target modification, contributing to reduced antibiotic effectiveness.

Gene Information

Gene Name: baeS
Allele: baeS
Encodes: sensor kinase component of the BaeRS two-component cell wall stress regulatory pair
Source Database: Reslit
Mechanism: mutation in baeS leads to decreased susceptibility to LYS228
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
Validation Method: whole-genome sequencing and susceptibility testing
Sequence Accession: MH697720|MH697721|MH697722|MH697723|MH697724|MH697725|MH697726|MH697727|MH697728

3

Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient

PMID 31787070 · 2023

The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.

Gene Information

Gene Name: baeS
Allele: baeS
Encodes: two-component response regulator
Source Database: Reslit
Organisms Tested In: • Escherichia coli
Validation Method: metagenomic read cloud sequencing and assembly

4

Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in Acinetobacter baumannii.

PMID 37345941 · 2023

Mutations in the two-component regulator BaeSR (D89V in BaeS and S104N in BaeR) mediate cefiderocol resistance in Acinetobacter baumannii by up-regulating efflux pump genes, particularly MFS transporters and MacAB-TolC. Additionally, the BaeS mutation increases virulence by up-regulating the paa operon.

Gene Information

Gene Name: baeS
Allele: baeS
Encodes: two-component system histidine kinase
Source Database: Reslit
Mechanism: mutation increases cefiderocol resistance
Confers Resistance To: Cefiderocol
Organisms Tested In: • Acinetobacter baumannii
Validation Method: mutant strain construction and MIC testing

5

Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.

PMID 38029076 · 2023

The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.

Gene Information

Gene Name: baeS
Allele: baes
Encodes: putative ABC transporter permease
Source Database: Reslit
Mechanism: gentamicin resistance
Confers Resistance To: Gentamicin
Organisms Tested In: • Streptococcus equi subsp. equi
Geographic Location: China
Validation Method: antimicrobial susceptibility testing
Sequence Accession: CP133957|CP133955|CP133956

6

Cefiderocol and Sulbactam-Durlobactam against Carbapenem-Resistant Acinetobacter baumannii.

PMID 38136764 · 2023

The study characterizes several AMR genes and mutations involved in resistance to cefiderocol in Acinetobacter baumannii, including blaPER-1, blaNDM-1, blaADC-25, blaADC-33, pirA, piuA, BaeS, BaeR, and specific mutations in PirA and PBP3.

Gene Information

Gene Name: baeS
Allele: BaeS
Encodes: two-component system regulator
Source Database: Reslit
Confers Resistance To: Cefiderocol
Organisms Tested In: • Acinetobacter baumannii
Validation Method: mutations of the BaeS (D89V) and BaeR (S104N) two-component system regulator

7

Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.

PMID 38459466 · 2024

The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.

Gene Information

Gene Name: baeS
Allele: baeS
Encodes: resistance-nodulation-cell division (RND) antibiotic efflux pump
Source Database: Reslit
Mechanism: antibiotic efflux
Confers Resistance To: AminoglycosideAminocoumarin
Organisms Tested In: • Escherichia coli
Geographic Location: South Africa
Validation Method: RGI analysis
Sequence Accession: NCBI:CP083125

8

Based on molecular docking and real-time PCR technology, the two-component system Bae SR was investigated on the mechanism of drug resistance in CRAB.

PMID 38622558 · 2024

The two-component system Bae SR was found to play a critical role in carbapenem resistance in CRAB, with increased expression of bae S and bae R genes correlating with higher resistance levels.

Gene Information

Gene Name: baeS
Allele: bae S
Encodes: histidine kinase
Source Database: Reslit
Mechanism: two-component system involved in drug resistance
Confers Resistance To: Carbapenem
Organisms Tested In: • Acinetobacter baumannii
Validation Method: fluorescence quantitative PCR and molecular docking
Sequence Accession: MK344183.1|MK344168.1