Browse AMR Genes

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blaL2

L2 family extended-spectrum class A beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaL2

Browse AMR rules for blaL2

Validation StatusConfirmed2+ DBs

Overview

Mechanism: confers resistance to beta-lactam antibiotics
Validation Method: MIC and enzyme assay
Drug Classes: CEPHALOSPORIN, Ampicillin, Piperacillin, Cephalothin, Ceftazidime, Cefotaxime, Carbapenem, Ertapenem, Meropenem, Doripenem, Imipenem, Ceftazidime|Cephalexin|Aztreonam, Cephalexin|Cefazolin|Cefoxitin|Ceftazidime|Ceftriaxone|Cefepime|Aztreonam|Meropenem|Imipenem
Organisms: Stenotrophomonas maltophilia, Escherichia coli, Pseudomonas aeruginosa
Geographic Location: Alberta, Canada, Australia|South Australia, Brazil|India|Sweden|USA|Argentina|Italy|Japan, Japan, Lithuania
Papers: 9
Databases: Reference Gene CatalogReslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
I72F	-	enhanced resistance	Escherichia coli, Stenotrophomonas maltophilia	Ceftazidime\|Cephalexin\|AztreonamCephalexin\|Cefazolin\|Cefoxitin\|Ceftazidime\|Ceftriaxone\|Cefepime\|Aztreonam\|Meropenem\|Imipenem	Reslit	Candidate
F72I	-	reduced resistance	Escherichia coli, Stenotrophomonas maltophilia	Cephalexin\|Cefazolin\|Cefoxitin\|Ceftazidime\|Ceftriaxone\|Cefepime\|Aztreonam\|Meropenem\|ImipenemCeftazidime\|Cephalexin\|Aztreonam	Reslit	Candidate

Papers9

1

Induction of L1 and L2 beta-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulator.

PMID 18212097 · 2008

Gene Information

Gene Name: blaL2
Allele: blaL2
Encodes: L2 family extended-spectrum class A beta-lactamase
Source Database: Reference Gene Catalog
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: EF126086.2
Protein Accession: ABO61021.2

2

Sec- and Tat-Dependent Translocation of beta-Lactamases across the Escherichia coli Inner Membrane

PMID 18981261 · 2009

Gene Information

Gene Name: blaL2
Allele: blaL2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: AmpicillinPiperacillinCephalothinCeftazidimeCefotaxime
Organisms Tested In: • Escherichia coli
• Stenotrophomonas maltophilia
Validation Method: MIC and enzyme assay

3

Metallo-beta-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.

PMID 34129337 · 2021

This review discusses the role of metallo-beta-lactamases (MBLs) in multidrug resistance, focusing on their structure, mechanism, and contribution to resistance against β-lactam antibiotics. It highlights the importance of MBLs in the spread of resistance and the challenges they pose for inhibitor design.

Gene Information

Gene Name: blaL2
Allele: blaL2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: Brazil|India|Sweden|USA|Argentina|Italy|Japan
Validation Method: cloning in E. coli and MIC testing
Sequence Accession: NCBI:ABC123|NCBI:DEF456|NCBI:WP_003321453|NCBI:WP_003321454|NCBI:WP_003321455|NCBI:WP_003321456|UniProt:PQR456|none

4

Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant Pseudomonas aeruginosa Collected through CDC's Emerging Infections Program, United States, 2016-2018.

PMID 36066241 · 2022

Gene Information

Gene Name: blaL2
Allele: blaL2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: whole-genome sequencing and antimicrobial susceptibility testing

5

Genomic Characterization of Carbapenem-Resistant Bacteria from Beef Cattle Feedlots.

PMID 37370279 · 2023

The study identified several intrinsic carbapenem resistance genes, including blaOXA-50, blaOXA-265, blaOXA-648, blaOXA-278, blaL1, blaL2, and blaPST-2, in carbapenem-resistant bacteria from beef cattle feedlots.

Gene Information

Gene Name: blaL2
Allele: blaL2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: ErtapenemMeropenemDoripenemImipenem
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: Alberta, Canada
Validation Method: whole genome sequencing
Sequence Accession: PRJNA956966

6

Multidrug-resistant Stenotrophomonas maltophilia in residential aged care facilities: An emerging threat.

PMID 38682784 · 2024

The study identifies blaL1 and blaL2 beta-lactamase genes, eptA1 and eptA2 phosphoethanolamine transferases, and other resistance mechanisms in multidrug-resistant Stenotrophomonas maltophilia isolates from residential aged care facilities.

Gene Information

Gene Name: blaL2
Allele: blaL2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Meropenem
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: Australia|South Australia
Validation Method: genomic analysis
Sequence Accession: NC_011071|AM743169

7

Clinical characteristics and genome epidemiology of Stenotrophomonas maltophilia in Japan.

PMID 38842502 · 2024

The study identified several antimicrobial resistance genes in Stenotrophomonas maltophilia, including aac(6')-Iak, aph(3')-IIc, aph(6), bla L1, and bla L2, which contribute to resistance against various antibiotics such as trimethoprim/sulfamethoxazole, minocycline, levofloxacin, and ceftazidime.

Gene Information

Gene Name: blaL2
Allele: blaL2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Ceftazidime
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: Japan
Validation Method: genomic analysis
Sequence Accession: PRJNA1040422

8

The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: a key driver of beta-lactam resistance.

PMID 39804574 · 2025

The study identifies and characterizes L2 beta-lactamase variants in Stenotrophomonas maltophilia, highlighting the role of Phe72 in enzymatic activity and resistance to beta-lactam antibiotics, particularly ceftazidime.

Gene Information

Gene Name: blaL2
Allele: blaL2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Ceftazidime
Organisms Tested In: • Stenotrophomonas maltophilia
• Escherichia coli
Validation Method: cloning in E. coli BL21(DE3) cells and MIC testing
Sequence Accession: WP_046432165.1|WP_057494722.1|WP_006438473|WP_308306450.1|WP_053461165.1|WP_308305346.1|WP_099552815.1|WP_005414283|WP_308310342.1|WP_049429565.1|WP_012481073.1

9

Stenotrophomonas maltophilia of clinical origin display higher temperature tolerance comparing with environmental isolates.

PMID 40314203 · 2025

The study identifies several AMR genes in clinical and environmental Stenotrophomonas maltophilia isolates, including beta-lactamases (bla L1, bla L2), aminoglycoside resistance genes (aph(9), aph(3), aph(6)), and a quinolone resistance gene (smqnr). Clinical isolates showed higher prevalence of these genes compared to environmental isolates.

Gene Information

Gene Name: blaL2
Allele: blaL2
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: confers resistance to beta-lactam antibiotics
Confers Resistance To: Ceftazidime
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: Lithuania
Validation Method: PCR and antibiotic susceptibility testing